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I (78 y.o. male) was diagnosed with NSCLC in March 2011 and in late May I started taking Iressa as a first line of treatment. For the first five months my only side effect was a mild rash. I then had swollen gums and stomach acid. Both quickly responded to antibiotics. 75 days between the March and May CT scans the tumor increased by 86% (from 4.9 x 4 cms). 50 days later in July, after taking Iressa, the CT scan revealed an 83% reduction. From March to July it reduced by 69% and in December, although subtle, there has been further reduction. April 2012. True to form, tumour started growing again after 10 months of Iressa treatment. Still looking healthy, active in garden and taking 4 to 6 miles weekly walks. Only side effect was mild rash mainly on body. Now switching to conventional Chemotherapy today 10th May.

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I have been using Iressa for about two month to treat cancer in my lungs. My doctor says this medication prevents cancer cells from growing. Of course, it was only my impression, but I thing Iressa improved my condition because I started feeling myself much better. And after using the medication for about a month my doctor carried out a number of tests and stated that the amount of cancer cells I my lugs decreased. I was really happy to hear that! Not I finally have hope thanks to Iressa!

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An immunotherapeutic combination product composed of LV305, an engineered lentiviral vector that both targets dendritic cells (DCs) and contains nucleic acids encoding the human tumor-associated cancer-testis antigen NY-ESO-1 (CTAG1), and G305, a cancer vaccine comprised of an NY-ESO-1 recombinant protein and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential synergistic immunostimulatory and antineoplastic activities.

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Patients who have had a previous diagnosis of cancer, are excluded except if have been adequately treated for non-melanoma skin cancer or carcinoma in situ of the cervix are eligible irrespective of when that treatment was given.

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This approval does not specify what line of crizotinib treatment should be used, meaning crizotinib could be used for first-line treatment of patients with advanced ALK-rearranged NSCLC.

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Black men between the age of 35 and 64 years of age have twice the risk compared to non-Hispanic Whites.

If the cancer is localized to the anus and pelvic lymph nodes, it may be used in combination with radiation therapy to achieve the best chance of killing all of the cancer cells (see \"Combined Modality (Chemoradiotherapy).

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Together, these recent investigations revealed that high resistance to current therapeutic treatments may result from several different structural and functional properties between the cancer progenitor cells and their further differentiated progeny, including certain molecular mechanisms that may contribute to their high resistance to current therapeutic treatments.

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Williams KJ, Telfer BA, Stratford IJ, Wedge SR (2002) ZD1839 (\'Iressa\'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model.

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As a consequence of these failures to prolong the lives of NSCLC patients, AstraZeneca withdrew its European Marketing Authorization Application for Iressa on January 4, 2005.

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Anderson Cancer Center Summary: Gefitinib, also known as Iressa, the once-promising targeted therapy for the treatment of nonsmall cell lung cancer, has proven as effective as chemotherapy as a second-line therapy for the disease with far fewer side effects, according to an international Phase III clinical trial.

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The confirmatory trial showed no significant survival benefit for those patients treated with Iressa.

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Our study found that patients who received Iressa and whose tumors had EGFR mutations will have an improved response rate and progression-free survival compared to docetaxel, but overall survival was similar in both treatment groups.

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On the basis of these survival benefits, erlotinib was approved in 2004 as a monotherapy for previously treated, locally advanced or metastatic NSCLC, and in 2005, in combination with gemcitabine for the first-line treatment of locally advanced, unresectable, or metastatic pancreatic cancer.

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There was a trend in favor of the Iressa, but it was not statistically significant - it missed literally by two weeks.

Combined and Multi-Modal Therapy.

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