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The response time was shorter than in other studies, possibly reflecting the use of continuous intravenous infusions.
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Cyclosporine is a powerful immunosuppressive agent used to treat a variety of diseases in dogs.
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The following are examples of some clinically significant CYP3A based drug interactions.
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Dogs with atopic dermatitis begin with once daily usage and then taper to a schedule more like every other day or less.
There is one possible explanation; since CyA has a high affinity to albumin and low density lipoprotein and distributes to erythrocytes, their qualitative and quantitative changes could have a great potential to modulate the distribution balance between adipose and lean tissue, resulting in TBW-independent drug disposition.
Although HPLC is considered the gold standard for measuring cyclosporine blood concentrations, HPLC is labor-intensive and not routinely offered for patient monitoring.
Furthermore, using moderate CYP3A inducers or strong CYP3A inhibitors is not recommended.
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Experimental evidence suggests that the effectiveness of cyclosporine is due to specific and reversible inhibition of immunocompetent lymphocytes in the G 0- or G 1-phase of the cell cycle.
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There were four cases of benign lymphocytic infiltration: 3 regressed spontaneously upon discontinuation of Cyclosporine, while the fourth regressed despite continuation of the drug.
Despite mostly positive findings and high ratings on the Jadad score, the placebocontrolled, randomised clinical trials of homotoxicology fail to demonstrate the efficacy of this therapeutic approach.
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Puede que haya algo de verdad en esta afirmacin, especialmente en las dietas en las que la gente tiene que pasar autntica hambre, afirm Julie Miller Jones, profesora de nutricin y ciencias alimentarias del College of St.
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