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There is one possible explanation; since CyA has a high affinity to albumin and low density lipoprotein and distributes to erythrocytes, their qualitative and quantitative changes could have a great potential to modulate the distribution balance between adipose and lean tissue, resulting in TBW-independent drug disposition.

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There were four cases of benign lymphocytic infiltration: 3 regressed spontaneously upon discontinuation of Cyclosporine, while the fourth regressed despite continuation of the drug.

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