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Cyclosporine is a powerful immunosuppressive agent used to treat a variety of diseases in dogs.

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The following are examples of some clinically significant CYP3A based drug interactions.

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There is one possible explanation; since CyA has a high affinity to albumin and low density lipoprotein and distributes to erythrocytes, their qualitative and quantitative changes could have a great potential to modulate the distribution balance between adipose and lean tissue, resulting in TBW-independent drug disposition.

Although HPLC is considered the gold standard for measuring cyclosporine blood concentrations, HPLC is labor-intensive and not routinely offered for patient monitoring.

Furthermore, using moderate CYP3A inducers or strong CYP3A inhibitors is not recommended.

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There were four cases of benign lymphocytic infiltration: 3 regressed spontaneously upon discontinuation of Cyclosporine, while the fourth regressed despite continuation of the drug.

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