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Table 2 summarizes the mean change from baseline to steady state in corrected QT interval (QT c) relative to placebo at the time of peak tolterodine (1 hour) and moxifloxacin (2 hour) concentrations.

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The mechanisms for UI are multiple including (i) overflow incontinence caused by detrusor atonia with a non-relaxing sphincter, (ii) lack of storage capacity caused by hyperreflexia or poor compliance, and (iii) low urethral resistance caused by denervation of the sphincters.

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Yamaguchi O, Nishizawa O, Takeda M et al: Efficacy, safety and tolerability of fesoterodine in Asian patients with overactive bladder.

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