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Distributed into milk in mice; not known whether tolterodine crosses the placenta or is distributed into human milk.
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Table 2 summarizes the mean change from baseline to steady state in corrected QT interval (QT c) relative to placebo at the time of peak tolterodine (1 hour) and moxifloxacin (2 hour) concentrations.
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N-Dealkylated tolterodine and 5-HM were major metabolites in all species.
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In LUTD, VUR is often low grade and US findings are normal, and there is no indication for performing VCUG in all children with LUTD, but the presence of febrile infections should be meticulously investigated.
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He said this would be a threshold dose based on the dosages of other ergot alkaloids.
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CISC was needed by 35% of patients after the first injection; 21% developed UTIs.
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The mechanisms for UI are multiple including (i) overflow incontinence caused by detrusor atonia with a non-relaxing sphincter, (ii) lack of storage capacity caused by hyperreflexia or poor compliance, and (iii) low urethral resistance caused by denervation of the sphincters.
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However, it is important first to make sure that the bladder symptoms are no due to some other problem such as bladder infection, prostate enlargement, or stress incontinence.
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Yamaguchi O, Nishizawa O, Takeda M et al: Efficacy, safety and tolerability of fesoterodine in Asian patients with overactive bladder.
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Post-void residual urine should be measured in toilet-trained children to exclude voiding abnormalities as a cause of UTI.
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Two pediatric phase 3 randomized, placebo-controlled, double-blind, 12-week studies were conducted using tolterodine extended release (tolterodine ER) capsules.
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If storage symptoms predominate, an overactive bladder due to idiopathic detrusor overactivity is the most likely cause if there is no indication of BOO from flow study.
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